Investigating how a specific inflammatory pathway affects immune regulation in organ transplants
Official title: The novel role of MIF-CD74 inflammatory pathway in immune regulation
Funded at Brigham and Women's Hospital · NIH-10992182 · Data updated 2026-11-12
This study is looking at how a specific protein and its receptor affect the immune system during organ transplants, with the goal of finding ways to help the body accept the new organ better and reduce the chances of rejection, which could lead to improved outcomes for people receiving transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $408,062 |
| NIH project number | 5R01AI179986-02 |
| Project ID | NIH-10992182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing or considering organ transplantation, particularly heart transplants.
✕Less likely to help
Patients who are not candidates for organ transplantation or those with conditions unrelated to alloimmunity may not benefit from this research.
What this research studies
This research explores the role of the macrophage migration inhibitory factor (MIF) and its receptor CD74 in regulating immune responses during organ transplantation. It aims to understand how inflammation impacts the stability and function of regulatory T cells (Tregs), which are crucial for preventing organ rejection. By inhibiting the MIF-CD74 pathway, the study seeks to enhance the immune regulation and promote long-term acceptance of transplanted organs, potentially leading to better outcomes for transplant recipients. The research utilizes animal models to test the effects of this pathway on T cell behavior and transplant survival.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection and enhancing the longevity of transplants.
How similar studies have gone: Previous research has shown promise in targeting inflammatory pathways for improving transplant outcomes, suggesting that this approach could be effective.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Azzi, Jamil — Brigham and Women's Hospital
- Study coordinator: Azzi, Jamil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.