Investigating how a specific immune cell receptor affects gut health and inflammation
Official title: ILC3 Syndecan-4 in the Regulation of Intestinal Health and Inflammation
Funded at Weill Medical Coll of Cornell Univ · NIH-11057567 · Data updated 2026-11-12
This study is looking at how certain immune cells in your gut help keep things healthy and manage inflammation, especially for people with inflammatory bowel disease (IBD) or colon cancer, by exploring how these cells interact with gut bacteria and a specific receptor that might help heal and balance the gut.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31DK134187-03 |
| Project ID | NIH-11057567 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with inflammatory bowel disease or those experiencing chronic gut inflammation.
✕Less likely to help
Patients with non-inflammatory gastrointestinal conditions or those without any gut-related issues may not benefit from this research.
What this research studies
This research focuses on understanding the role of group 3 innate lymphoid cells (ILC3s) in maintaining intestinal health and regulating inflammation, particularly in conditions like inflammatory bowel disease (IBD) and colon cancer. The study examines how these immune cells interact with gut microbes and the mechanisms that lead to chronic inflammation and tissue damage. By exploring the function of a receptor called syndecan-4 on ILC3s, the research aims to uncover new pathways that could promote healing and restore balance in the gut environment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing inflammatory bowel disease and improving gut health.
How similar studies have gone: Previous research has shown promising results in understanding immune cell functions in gut health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Fiedler, Brooke Elizabeth — Weill Medical Coll of Cornell Univ
- Study coordinator: Fiedler, Brooke Elizabeth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.