Investigating how a specific genetic variant affects the risk of Alzheimer's disease
Define the effect of CLU SNP on the risk to Alzheimer's disease
['FUNDING_OTHER'] · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · NIH-10526184
This study is looking at how a specific gene might affect the development of Alzheimer's disease, using special lab-grown brain cells to help us learn more about the disease and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BECKMAN RESEARCH INSTITUTE/CITY OF HOPE (nih funded) |
| Locations | 1 site (DUARTE, UNITED STATES) |
| Trial ID | NIH-10526184 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a genetic variant in the development of Alzheimer's disease, the most common form of dementia among the elderly. By utilizing human induced pluripotent stem cells (hiPSCs) and directly reprogrammed cells, the study aims to create models that reflect age-related changes in brain cells. This approach allows researchers to explore the molecular mechanisms of Alzheimer's and potentially identify new therapeutic targets. The research combines insights from both human and animal studies to enhance our understanding of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals, particularly those with a family history of Alzheimer's disease or those who carry specific genetic variants associated with increased risk.
Not a fit: Patients who are not elderly or do not have a genetic predisposition to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating Alzheimer's disease.
How similar studies have performed: Previous research using human stem cells to model Alzheimer's disease has shown promise, indicating that this approach could yield valuable insights.
Where this research is happening
DUARTE, UNITED STATES
- BECKMAN RESEARCH INSTITUTE/CITY OF HOPE — DUARTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, YANHONG — BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
- Study coordinator: SHI, YANHONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease