Investigating how a specific genetic mutation affects nerve cell development
Official title: The role of the dz217 mutation in somatosensory dendrite morphogenesis
Funded at Albert Einstein College of Medicine · NIH-11232157 · Data updated 2026-11-12
This study is looking at how certain genes affect the growth of tiny branches on nerve cells, which are important for how our brain works, and it uses a small worm called C. elegans to see how a specific mutation changes these branches; the goal is to learn more about how nerve cells connect, which could help us understand conditions like autism better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | January 1, 2025 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $51,768 |
| NIH project number | 3R01NS129992-02S1 |
| Project ID | NIH-11232157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autism spectrum disorder or those interested in the genetic factors influencing neural development.
✕Less likely to help
Patients without autism spectrum disorder or those not affected by genetic mutations related to dendrite development may not benefit from this research.
What this research studies
This research focuses on understanding the genetic and molecular mechanisms that influence the development of dendrites, which are essential for proper neural circuit function. Using the model organism C. elegans, the study examines how the dz217 mutation impacts the branching of dendrites in specific neurons. By identifying genetic factors that regulate dendrite morphology, the research aims to uncover fundamental insights into how nerve cells communicate and function. This could lead to a better understanding of conditions like autism spectrum disorder, where neural connectivity may be affected.
Why it matters
Potential benefit: If successful, this research could provide insights into the biological underpinnings of autism spectrum disorder, potentially leading to new therapeutic strategies.
How similar studies have gone: Previous research has shown success in using genetic models like C. elegans to study neural development, indicating that this approach is promising.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Buelow, Hannes Erich — Albert Einstein College of Medicine
- Study coordinator: Buelow, Hannes Erich
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.