Investigating how a specific gene mutation causes Parkinson's disease in rat models
Exploring mechanisms of Parkinson's disease-linked D620N VPS35 in rat models
This study is looking into how a specific gene mutation related to Parkinson's disease affects brain cells that produce dopamine, using adult rats to find new ways to treat the condition and improve understanding of how the disease progresses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10895516 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind Parkinson's disease, particularly how a mutation in the VPS35 gene leads to the degeneration of dopamine-producing neurons. Using a novel model in adult rats, the study will explore the effects of the D620N mutation on neuronal health and function. By examining the cellular processes involved, the research aims to uncover potential pathways for developing new treatments for Parkinson's disease. The findings could provide insights into the disease's progression and help identify targets for therapeutic intervention.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with a genetic predisposition to Parkinson's disease, particularly those with the D620N VPS35 mutation.
Not a fit: Patients without a genetic link to Parkinson's disease or those with other forms of the disease unrelated to VPS35 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of disease-modifying therapies for Parkinson's disease.
How similar studies have performed: Other research has shown success in using animal models to investigate genetic mutations related to Parkinson's disease, making this approach both relevant and promising.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Moore, Darren John — Van Andel Research Institute
- Study coordinator: Moore, Darren John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.