Investigating how a specific gene deficiency affects lung blood vessel health in pulmonary hypertension.
Role of Endothelial SOX17 Deficiency in the Pathogenesis of Pulmonary Hypertension
This study is looking at how a gene called SOX17 affects pulmonary hypertension, a condition that raises blood pressure in the lungs, and aims to find new ways to help treat it by using animal models to see what happens when this gene is missing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11169531 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the SOX17 gene in the development of pulmonary hypertension (PH), a condition that causes high blood pressure in the lungs and can lead to serious heart problems. The researchers will use animal models to explore how the absence of SOX17 in endothelial cells contributes to changes in blood vessel structure and function. By examining the molecular mechanisms involved, they aim to identify potential new treatments that could help manage or reverse the effects of PH in patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pulmonary hypertension, particularly those with genetic mutations or congenital heart disease.
Not a fit: Patients with pulmonary hypertension caused by factors unrelated to genetic mutations or endothelial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating pulmonary hypertension, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in pulmonary hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Dai, Zhiyu — Washington University
- Study coordinator: Dai, Zhiyu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.