Investigating how a specific gene affects the development of the notochord and spine.
Official title: Uncovering the role of inppl1a in notochord vacuolation and the development of a straight body axis.
Funded at University of Texas at Austin · NIH-10951518 · Data updated 2026-11-12
This study is looking at how a specific gene called inppl1a affects the development of a key structure in fish that supports the spine, which could help us understand spinal problems in people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | September 21, 2023 |
| Project end | September 20, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,269 |
| NIH project number | 5F31HD114419-02 |
| Project ID | NIH-10951518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with congenital spinal deformities or those interested in genetic factors affecting spine development.
✕Less likely to help
Patients without spinal deformities or those not affected by genetic conditions related to notochord development may not benefit from this research.
What this research studies
This research focuses on understanding the role of the inppl1a gene in the development of the notochord, a crucial structure that supports the spine in vertebrates. Using zebrafish as a model organism, the study employs advanced imaging techniques and genetic analysis to explore how mutations in this gene lead to defects in notochord formation and associated spinal issues. By examining the mechanics of notochord cell inflation, the research aims to uncover fundamental insights into spinal development and potential malformations.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for spinal deformities such as scoliosis.
How similar studies have gone: Previous research has shown success in using zebrafish models to study spinal development, indicating that this approach is promising.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Voigt, Brittney — University of Texas at Austin
- Study coordinator: Voigt, Brittney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.