Investigating how a specific gene affects social behavior differences in adolescents
Official title: Foxp2 genetic control of sex differences in amygdala-driven social behavior
Funded at Children's Research Institute · NIH-10992741 · Data updated 2026-11-12
This study is looking at how a specific gene called Foxp2 affects social behaviors in young mice, which could help us understand more about how genetics influence social and emotional growth during adolescence.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | July 23, 2024 |
| Project end | July 22, 2026 |
| Funding year | 2024 |
| Award (this year) | $497,652 |
| NIH project number | 1R21MH135324-01A1 |
| Project ID | NIH-10992741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are adolescents aged 12-20 who exhibit social-emotional challenges or neurodevelopmental disorders such as ADHD or autism.
✕Less likely to help
Patients outside the age range of 12-20 or those without social-emotional challenges may not receive direct benefits from this research.
What this research studies
This research explores the role of the Foxp2 gene in the development of social behaviors during adolescence, a critical period for emotional and social growth. By using advanced CRISPR-Cas gene editing techniques, the study will specifically target the Foxp2 gene in the medial amygdala of male and female mice to observe changes in social behavior. The findings aim to enhance our understanding of how genetic factors contribute to social-emotional development and potential disorders in adolescents.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic underpinnings of social behavior, potentially informing interventions for adolescents with neurodevelopmental disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in social behavior, making this approach both relevant and potentially impactful.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Corbin, Joshua G — Children's Research Institute
- Study coordinator: Corbin, Joshua G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.