Investigating how a specific gene affects smooth muscle cells in heart disease.

Who could benefit from this research

What this research studies

This research focuses on understanding the role of a gene called Twist1 in the behavior of smooth muscle cells (SMCs) during the development of atherosclerosis, a condition that can lead to heart disease. By using advanced techniques like single cell RNA sequencing, the researchers aim to observe how SMCs change their characteristics and contribute to the formation of arterial plaques. The study will explore how these changes can influence disease progression and risk factors associated with coronary artery disease. Ultimately, the goal is to identify potential therapeutic targets that could improve heart health.

Why it matters

Where this research is happening

• Univ of North Carolina Chapel Hill
  Chapel Hill, United States Active

Researchers

• Principal investigator: Wirka, Robert — Univ of North Carolina Chapel Hill
• Study coordinator: Wirka, Robert

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.