Investigating how a specific gene affects smooth muscle cells in heart disease.
The role of Twist1 in SMC phenotypic modulation during atherosclerosis
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10989901
This study is looking at how a gene called Twist1 affects smooth muscle cells in your arteries as they change during atherosclerosis, which can lead to heart disease, to find new ways to help keep your heart healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10989901 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of a gene called Twist1 in the behavior of smooth muscle cells (SMCs) during the development of atherosclerosis, a condition that can lead to heart disease. By using advanced techniques like single cell RNA sequencing, the researchers aim to observe how SMCs change their characteristics and contribute to the formation of arterial plaques. The study will explore how these changes can influence disease progression and risk factors associated with coronary artery disease. Ultimately, the goal is to identify potential therapeutic targets that could improve heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients without cardiovascular risk factors or those with non-atherosclerotic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart disease by targeting specific cellular processes.
How similar studies have performed: Previous research has shown promising results in understanding the genetic factors influencing atherosclerosis, suggesting that this approach could yield valuable insights.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WIRKA, ROBERT — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: WIRKA, ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.