Investigating how a specific gene affects lung health and fibrosis
Mechanistic studies of the genetic contribution of desmoplakin to pulmonary fibrosis in alveolar type 2 cells
This study is looking at how a specific gene called desmoplakin affects lung health in people with pulmonary fibrosis, aiming to learn more about how our lungs repair themselves and find better ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10903825 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the desmoplakin gene in pulmonary fibrosis, a condition that affects lung function. By studying how genetic variations influence the behavior of alveolar type 2 cells, which are crucial for lung repair and maintenance, the research aims to uncover the mechanisms behind lung diseases. The team will use advanced techniques to model these cells and analyze how changes in desmoplakin impact their function, particularly in response to injury. This could lead to insights into how to better manage or treat pulmonary fibrosis.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with a genetic predisposition to pulmonary fibrosis or related lung diseases.
Not a fit: Patients with lung conditions unrelated to genetic factors or those without a history of pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating pulmonary fibrosis, improving lung health for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding genetic contributions to lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Wilson, Andrew a — Boston University Medical Campus
- Study coordinator: Wilson, Andrew a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.