Investigating how a specific gene affects kidney function and blood pressure in older adults
Epigenetic Regulation of Kidney Function and Blood Pressure
This study is looking at how a gene called KDM6A affects kidney health and blood pressure, especially in older adults who often struggle with high blood pressure, to find new ways to help manage this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10579236 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a gene called KDM6A in regulating kidney function and blood pressure, particularly in older adults who are more prone to hypertension. The study will use advanced techniques, including gene knockout and epigenetic analysis, to explore how the absence of KDM6A may contribute to high blood pressure and impaired kidney function. By examining these mechanisms, the research aims to uncover potential therapeutic targets for managing hypertension in the elderly population.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those experiencing hypertension or related kidney issues.
Not a fit: Patients who are younger and do not have hypertension or kidney function concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for hypertension in older adults, improving their overall health and quality of life.
How similar studies have performed: While the specific role of KDM6A in hypertension has not been extensively studied, similar research approaches have shown promise in understanding genetic influences on blood pressure regulation.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Sun, Zhongjie — University of Tennessee Health Sci Ctr
- Study coordinator: Sun, Zhongjie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.