Investigating how a specific gene affects heart disease risk
Official title: From genotype to phenotype in a GWAS locus: the role of REST in atherosclerosis
Funded at Johns Hopkins University · NIH-11013430 · Data updated 2026-11-12
This study is looking at how certain genes, especially one called REST, might affect heart disease, and it aims to find new ways to prevent it, which could help tailor treatments for patients based on their unique genetic makeup.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $171,720 |
| NIH project number | 5K08HL166690-03 |
| Project ID | NIH-11013430 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of atherosclerotic cardiovascular disease or those diagnosed with related conditions.
✕Less likely to help
Patients without a genetic predisposition to atherosclerosis or those with unrelated cardiovascular conditions may not benefit from this research.
What this research studies
This research focuses on understanding the genetic factors that contribute to atherosclerotic cardiovascular disease (ASCVD), a leading cause of death. The project will explore how variations in the RE-1 silencing transcription factor (REST) gene influence the development of atherosclerosis, using advanced techniques like CRISPR-Cas9 to edit genes in human stem cells. By identifying the mechanisms through which these genetic factors operate, the research aims to uncover new therapeutic targets for preventing heart disease. Patients may benefit from insights that could lead to personalized treatment strategies based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that reduce the risk of heart disease based on individual genetic makeup.
How similar studies have gone: Previous research has successfully identified genetic factors influencing cardiovascular disease, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Arvanitis, Marios — Johns Hopkins University
- Study coordinator: Arvanitis, Marios
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.