Investigating how a specific gene affects eye pressure in glaucoma patients
Targeting FMNL2/Rho-GTPase Pathway for IOP Regulation in Glaucoma
['FUNDING_R21'] · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · NIH-11003323
This study is looking at how a specific gene might affect eye pressure in African Americans, who are more likely to develop glaucoma, to help find better treatments for this condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NORTH TEXAS HLTH SCI CTR (nih funded) |
| Locations | 1 site (FORT WORTH, UNITED STATES) |
| Trial ID | NIH-11003323 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the mechanisms that regulate intraocular pressure (IOP) in African Americans, who are disproportionately affected by primary open angle glaucoma (POAG). The study aims to explore the role of the FMNL2 gene and its associated protein in the contraction and relaxation of trabecular meshwork (TM) cells, which are crucial for maintaining normal IOP. By utilizing genetic analysis and biochemical methods, the research seeks to identify potential therapeutic targets that could lead to improved treatments for glaucoma in this population. The findings could provide insights into the unique genetic factors influencing glaucoma risk among African Americans.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American individuals diagnosed with primary open angle glaucoma or those at high risk for developing the condition.
Not a fit: Patients who do not identify as African American or those with other forms of glaucoma unrelated to the FMNL2 gene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments specifically tailored for African Americans suffering from glaucoma, potentially reducing the risk of blindness.
How similar studies have performed: While research on glaucoma has been extensive, this specific focus on the FMNL2 gene in African Americans is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
FORT WORTH, UNITED STATES
- UNIVERSITY OF NORTH TEXAS HLTH SCI CTR — FORT WORTH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELLIS, DORETTE Z — UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
- Study coordinator: ELLIS, DORETTE Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.