Investigating how a specific gene affects eye pressure in glaucoma patients
Official title: Targeting FMNL2/Rho-GTPase Pathway for IOP Regulation in Glaucoma
Funded at University of North Texas Hlth Sci Ctr · NIH-11003323 · Data updated 2026-11-12
This study is looking at how a specific gene might affect eye pressure in African Americans, who are more likely to develop glaucoma, to help find better treatments for this condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas Hlth Sci Ctr NIH-funded |
| Lab location | 1 site (Fort Worth, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $185,000 |
| NIH project number | 5R21EY034831-02 |
| Project ID | NIH-11003323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American individuals diagnosed with primary open angle glaucoma or those at high risk for developing the condition.
✕Less likely to help
Patients who do not identify as African American or those with other forms of glaucoma unrelated to the FMNL2 gene may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms that regulate intraocular pressure (IOP) in African Americans, who are disproportionately affected by primary open angle glaucoma (POAG). The study aims to explore the role of the FMNL2 gene and its associated protein in the contraction and relaxation of trabecular meshwork (TM) cells, which are crucial for maintaining normal IOP. By utilizing genetic analysis and biochemical methods, the research seeks to identify potential therapeutic targets that could lead to improved treatments for glaucoma in this population. The findings could provide insights into the unique genetic factors influencing glaucoma risk among African Americans.
Why it matters
Potential benefit: If successful, this research could lead to new treatments specifically tailored for African Americans suffering from glaucoma, potentially reducing the risk of blindness.
How similar studies have gone: While research on glaucoma has been extensive, this specific focus on the FMNL2 gene in African Americans is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
-
University of North Texas Hlth Sci Ctr
Fort Worth, United States Active
Researchers
- Principal investigator: Ellis, Dorette Z — University of North Texas Hlth Sci Ctr
- Study coordinator: Ellis, Dorette Z
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Understanding how glaucoma genes control eye cell function
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.