Investigating how a specific gene affects drug metabolism in children
Official title: Functional connection between the growth factor independence-1b and post-neonatal regulation of biotransformation genes
Funded at University of Cincinnati · NIH-10681617 · Data updated 2026-11-12
This study is looking at how a specific gene affects how children process medications as they grow, especially in their early years, to help us understand why some kids might react differently to drugs.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 8, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $445,500 |
| NIH project number | 1R21HD112071-01 |
| Project ID | NIH-10681617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children and young adults under 21 years old who may require medication for various conditions.
✕Less likely to help
Patients who are over 21 years old or those not undergoing treatment that involves drug metabolism may not benefit from this research.
What this research studies
This research explores the role of the growth factor independence-1b gene in regulating drug metabolism during the postnatal period in children. It aims to understand how this gene influences the expression of various enzymes responsible for breaking down medications, particularly during the critical early stages of life. By examining the interactions between this gene and inflammatory signals, the study seeks to uncover mechanisms that could impact how children process drugs. The research employs techniques such as gene overexpression and knockdown to analyze these relationships.
Why it matters
Potential benefit: If successful, this research could lead to improved drug dosing and safety for children, enhancing their treatment outcomes.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation of drug metabolism, indicating that this approach has potential for success.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Yan, Bingfang — University of Cincinnati
- Study coordinator: Yan, Bingfang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.