Investigating how a specific gene affects brain drainage in Alzheimer's disease
Role of apoE-mediated meningeal lymphatic remodeling in the pathophysiology of Alzheimer’s disease
['FUNDING_OTHER'] · MAYO CLINIC JACKSONVILLE · NIH-10734287
This study is looking at how a specific gene related to Alzheimer's disease affects the brain's drainage system as we age, and it aims to find new ways to help people with Alzheimer's by understanding how this process works.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10734287 on ClinicalTrials.gov |
What this research studies
This research explores the role of the apolipoprotein E ε4 (APOE4) gene in the function of meningeal lymphatic vessels, which are crucial for draining fluid from the brain. It aims to understand how aging and the presence of the APOE4 allele impact this drainage system and contribute to the pathology of Alzheimer's disease. By using advanced mouse models, the study will examine the interactions between immune cells and lymphatic endothelial cells in the brain, which may lead to increased neuroinflammation and amyloid buildup. The findings could provide insights into new therapeutic strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older, particularly those with a genetic predisposition to Alzheimer's disease, such as carriers of the APOE4 allele.
Not a fit: Patients who do not have Alzheimer's disease or related cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve brain drainage and reduce the progression of Alzheimer's disease.
How similar studies have performed: While the specific approach of this research is novel, related studies have shown that targeting lymphatic function can influence neurodegenerative processes.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DA MESQUITA, SANDRO — MAYO CLINIC JACKSONVILLE
- Study coordinator: DA MESQUITA, SANDRO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.