Investigating how a specific gene affects brain development in children with Down syndrome
Establishing the role of Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A trisomy in juvenile plasticity impairment in Down Syndrome
This study is looking at how certain genes, especially one called DYRK1A, affect brain development in kids with Down syndrome, using mice to learn more about how we might help improve thinking skills in these children.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11070407 on NIH RePORTER |
What this research studies
This research explores the genetic and molecular factors that contribute to developmental delays in individuals with Down syndrome, focusing on how trisomy affects brain development during critical juvenile periods. Using a mouse model, the study examines how the gene DYRK1A influences brain plasticity, particularly in response to visual stimuli. By understanding these mechanisms, the research aims to identify potential therapeutic targets that could improve cognitive function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Down syndrome who may experience cognitive delays.
Not a fit: Patients without Down syndrome or those who do not exhibit cognitive impairments related to trisomy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cognitive abilities in children with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on cognitive function in Down syndrome, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: William, Christopher Maged — New York University School of Medicine
- Study coordinator: William, Christopher Maged
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.