Investigating how a specific factor influences breast cancer spread
Role of SOX9 mammary stem cell factor in metastasis
This study is looking at how a protein called SOX9 helps breast cancer cells spread to other parts of the body, with the goal of finding new ways to stop this from happening and improve treatment options for patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10907454 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the SOX9 factor in breast cancer metastasis, particularly how it affects the ability of cancer cells to spread and grow in new locations. The study uses advanced mammary tumor models to track SOX9 levels in cancer cells, aiming to uncover the genetic programs that allow these cells to maintain their stem-like properties during metastasis. By identifying the mechanisms that regulate SOX9 and its impact on cancer stem cells, the research seeks to provide insights into potential therapeutic targets for preventing cancer spread.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those with aggressive or metastatic forms of the disease.
Not a fit: Patients with non-breast cancer types or those whose cancer has not metastasized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating metastatic breast cancer, improving patient outcomes.
How similar studies have performed: Previous research has shown promising results in targeting cancer stem cells, suggesting that this approach may lead to significant advancements in cancer treatment.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Guo, Wenjun — Albert Einstein College of Medicine
- Study coordinator: Guo, Wenjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.