Investigating how a specific estrogen affects aging and health differently in men and women
Role of estrogen receptor-a in aging and sex-specific responses to 17a-estradiol
This study is looking at a compound called 17α-estradiol to see if it can help improve health and possibly help men live longer by understanding how it works in the brain and affects aging and metabolism differently in men and women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10885098 on NIH RePORTER |
What this research studies
This research focuses on the effects of 17α-estradiol, a compound that may improve health and longevity, particularly in males. The study aims to understand how this compound interacts with estrogen receptors in the brain and how it influences aging and metabolism in a sex-specific manner. By examining the mechanisms behind these effects, the research seeks to determine if targeting estrogen receptors can enhance healthspan and potentially extend lifespan. Patients may benefit from insights gained about sex differences in aging and metabolic health.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include older adults, particularly males, who are interested in interventions for extending healthspan.
Not a fit: Patients who are not experiencing age-related health issues or who are not within the target age group may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve health and longevity, particularly for aging populations.
How similar studies have performed: Previous studies have shown promising results with similar compounds in extending lifespan in animal models, indicating potential for success in this research.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Stout, Michael B — Oklahoma Medical Research Foundation
- Study coordinator: Stout, Michael B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.