Investigating how a specific enzyme in fruit flies responds to oxidative stress in the eye
Official title: Characterizing Ahcy as a redox regulated enzyme in the Drosophila eye under oxidative stress
Funded at Purdue University · NIH-10902811 · Data updated 2026-11-12
This study is looking at how oxidative stress impacts a specific enzyme in fruit fly eyes, which could help us understand similar issues in human eye health, especially related to diseases caused by oxidative stress.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | March 28, 2024 |
| Project end | July 14, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31EY036754-01A1 |
| Project ID | NIH-10902811 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals at risk for or suffering from oxidative stress-related eye disorders, such as diabetic retinopathy.
✕Less likely to help
Patients with non-oxidative stress-related eye conditions may not receive any benefit from this research.
What this research studies
This research focuses on understanding how oxidative stress affects the enzyme Adenosylhomocysteinase (Ahcy) in the eyes of fruit flies, which can provide insights into similar processes in humans. By inducing oxidative stress in Drosophila cells and examining the resulting changes in enzyme activity and gene expression, the study aims to uncover the mechanisms behind oxidative stress-related ocular diseases. The approach includes in vitro assays, biochemical analysis, genome-wide sequencing, and genetic manipulation to explore the role of Ahcy in protecting against oxidative damage.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating ocular diseases linked to oxidative stress.
How similar studies have gone: While the specific approach of studying Ahcy in Drosophila under oxidative stress is novel, similar research has shown promise in understanding oxidative stress mechanisms in other contexts.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Stanhope, Sarah — Purdue University
- Study coordinator: Stanhope, Sarah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.