Investigating how a specific enzyme in fat cells affects energy use and obesity
The Role of Mitochondrial TNAP in Adaptive Thermogenesis
['FUNDING_CAREER'] · DANA-FARBER CANCER INST · NIH-10983323
This study is looking at how a specific enzyme in fat cells affects energy use and weight gain, using special mice to see if understanding this could help find new ways to treat obesity and diabetes.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DANA-FARBER CANCER INST (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10983323 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of mitochondrial tissue-nonspecific alkaline phosphatase (TNAP) in fat cells and its impact on energy expenditure and obesity. By using genetically modified mice that express TNAP in their adipose tissues, the study aims to explore how this enzyme influences metabolic processes related to obesity and diabetes. The researchers will employ biochemical techniques and cell imaging to analyze the localization and function of TNAP, which could lead to new insights into obesity treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of obesity or obesity-related diabetes, particularly those with metabolic dysfunction.
Not a fit: Patients who are not affected by obesity or metabolic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic strategies for preventing and treating obesity and related metabolic disorders.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in adipose tissue for obesity treatment, indicating potential success for this approach.
Where this research is happening
BOSTON, UNITED STATES
- DANA-FARBER CANCER INST — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, YIZHI — DANA-FARBER CANCER INST
- Study coordinator: SUN, YIZHI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.