Investigating how a specific enzyme contributes to lung disease caused by low oxygen levels.
Endothelial NOX1-Mediated AMPKa1 Propagates Hypoxia-Induced Pulmonary Hypertension via the CIP/KIP family of CDK inhibitors
This study is looking at how a specific enzyme affects lung cells in people with pulmonary arterial hypertension (PAH), which is a serious lung condition, to find new ways to help treat it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11031309 on NIH RePORTER |
What this research studies
This research focuses on pulmonary arterial hypertension (PAH), a serious lung condition that can arise from low oxygen levels and oxidative stress. The study aims to understand how the enzyme NADPH oxidase 1 (NOX1) and its signaling pathways affect the growth and behavior of lung cells in this disease. By using animal models, researchers will explore the role of AMPKα1, a protein that may influence cell proliferation and survival in the context of PAH. The findings could lead to new insights into the mechanisms of PAH and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension or those at risk due to genetic or environmental factors.
Not a fit: Patients with other forms of pulmonary hypertension not related to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for pulmonary arterial hypertension, improving outcomes for patients with this condition.
How similar studies have performed: Previous research has shown promising results in understanding the role of oxidative stress in pulmonary diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Goossen, Christian J — University of Pittsburgh at Pittsburgh
- Study coordinator: Goossen, Christian J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.