Investigating how a specific enzyme contributes to lung disease caused by low oxygen levels.

Who could benefit from this research

What this research studies

This research focuses on pulmonary arterial hypertension (PAH), a serious lung condition that can arise from low oxygen levels and oxidative stress. The study aims to understand how the enzyme NADPH oxidase 1 (NOX1) and its signaling pathways affect the growth and behavior of lung cells in this disease. By using animal models, researchers will explore the role of AMPKα1, a protein that may influence cell proliferation and survival in the context of PAH. The findings could lead to new insights into the mechanisms of PAH and potential therapeutic targets.

Why it matters

Where this research is happening

• University of Pittsburgh at Pittsburgh
  Pittsburgh, United States Active

Researchers

• Principal investigator: Goossen, Christian J — University of Pittsburgh at Pittsburgh
• Study coordinator: Goossen, Christian J

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.