Investigating how a specific enzyme affects tissue repair and regeneration
Chemical, Structural and Cell-Signaling Interrogation of 15-Prostanglandin Dehydrogenase in Tissue Repair and Regeneration
This study is looking at a special enzyme that helps your body heal after injuries or illnesses, and it's testing new medicines that could make recovery faster and better for people undergoing treatments like bone marrow transplants or liver repairs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11097356 on NIH RePORTER |
What this research studies
This research focuses on the enzyme 15-prostaglandin dehydrogenase (15-PGDH), which plays a crucial role in regulating tissue growth and repair in response to injury or disease. By developing small molecule inhibitors of this enzyme, the research aims to enhance recovery from various conditions, such as bone marrow transplantation and liver tissue regrowth. The team will utilize advanced techniques in medicinal chemistry and structural biology to understand how these inhibitors work at a molecular level. Patients may benefit from improved treatments for conditions characterized by tissue damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults experiencing conditions related to tissue damage, such as those recovering from surgeries or suffering from diseases like ulcerative colitis.
Not a fit: Patients with conditions unrelated to tissue repair or regeneration may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery and healing in patients with tissue damage.
How similar studies have performed: Other research has shown promising results with similar approaches targeting 15-PGDH in various disease models.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Ready, Joseph M — Ut Southwestern Medical Center
- Study coordinator: Ready, Joseph M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.