Investigating how a specific enzyme affects memory loss in Alzheimer's disease.
Phospholipase D1 Mediated Early Events Affecting Synaptic Dysfunction in Alzheimer's Disease and Related Dementia
This study is looking at how a protein called PLD1 might cause memory problems in Alzheimer's and similar conditions, using mouse models to find ways to help improve thinking skills for people affected by these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10809658 on NIH RePORTER |
What this research studies
This research focuses on understanding the early events that lead to synaptic dysfunction in Alzheimer's disease and related dementias. The team will explore how elevated levels of phospholipase D1 (PLD1) contribute to memory deficits by studying its effects in preclinical mouse models. By identifying the mechanisms behind synaptic dysfunction, the research aims to uncover potential therapeutic targets for improving cognitive function in affected individuals. Patients may benefit from insights gained about the role of PLD1 in Alzheimer's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those experiencing early cognitive deficits.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to synaptic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that slow down or prevent memory loss in Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding synaptic dysfunction in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Krishnan, Balaji — University of Texas Med Br Galveston
- Study coordinator: Krishnan, Balaji
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.