Investigating how a specific enzyme affects liver function and insulin resistance
Signaling and metabolic functions of nSMase-2 in hepatic steatosis and onset of insulin resistance
['FUNDING_R01'] · UNIVERSITY OF KENTUCKY · NIH-10918321
This study is looking at how a specific enzyme in the liver affects insulin's ability to manage blood sugar, with the goal of finding new treatments to help people with insulin resistance and type II diabetes feel better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-10918321 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of an enzyme called Neutral Sphingomyelinase-2 (nSMase-2) in the liver's response to insulin, which is crucial for managing blood sugar levels. The study aims to explore how this enzyme influences the production of ceramide, a lipid that may contribute to insulin resistance and type II diabetes. By examining the mechanisms involved, the research seeks to identify targeted therapies that could improve insulin sensitivity in patients. The approach includes both laboratory studies and potential applications for clinical treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing insulin resistance or metabolic syndrome, particularly those at risk for type II diabetes.
Not a fit: Patients who do not have insulin resistance or related metabolic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and help manage or prevent type II diabetes.
How similar studies have performed: Previous research has shown promising results in targeting ceramide pathways for metabolic syndrome, indicating potential for success in this novel approach.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIKOLOVA-KARAKASHIAN, MARIANA N — UNIVERSITY OF KENTUCKY
- Study coordinator: NIKOLOVA-KARAKASHIAN, MARIANA N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Animal Disease Models