Investigating how a specific enzyme affects liver function and insulin resistance
Official title: Signaling and metabolic functions of nSMase-2 in hepatic steatosis and onset of insulin resistance
Funded at University of Kentucky · NIH-10918321 · Data updated 2026-11-12
This study is looking at how a specific enzyme in the liver affects insulin's ability to manage blood sugar, with the goal of finding new treatments to help people with insulin resistance and type II diabetes feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $580,341 |
| NIH project number | 5R01DK135267-02 |
| Project ID | NIH-10918321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults experiencing insulin resistance or metabolic syndrome, particularly those at risk for type II diabetes.
✕Less likely to help
Patients who do not have insulin resistance or related metabolic conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of an enzyme called Neutral Sphingomyelinase-2 (nSMase-2) in the liver's response to insulin, which is crucial for managing blood sugar levels. The study aims to explore how this enzyme influences the production of ceramide, a lipid that may contribute to insulin resistance and type II diabetes. By examining the mechanisms involved, the research seeks to identify targeted therapies that could improve insulin sensitivity in patients. The approach includes both laboratory studies and potential applications for clinical treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve insulin sensitivity and help manage or prevent type II diabetes.
How similar studies have gone: Previous research has shown promising results in targeting ceramide pathways for metabolic syndrome, indicating potential for success in this novel approach.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Nikolova-Karakashian, Mariana N — University of Kentucky
- Study coordinator: Nikolova-Karakashian, Mariana N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.