Investigating how a specific enzyme affects liver disease related to alcohol consumption
Phosphodiesterase 4 mediated pathogenic mechanisms in alcohol associated liver disease
This study is looking at how a specific enzyme called PDE4 affects liver damage from drinking alcohol, with the hope of finding new ways to help people with alcohol-related liver problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-10890040 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of phosphodiesterase 4 (PDE4) in alcohol-associated liver disease (ALD), which affects a significant portion of the population. The study examines how alcohol consumption influences the expression of PDE4 in the liver and how this enzyme contributes to liver damage and metabolic dysfunction. By using animal and cell models, the researchers aim to uncover the mechanisms by which PDE4 affects lipid metabolism and cell survival in the context of ALD. The ultimate goal is to identify potential therapeutic targets that could mitigate liver injury caused by alcohol.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease or those at risk due to heavy alcohol consumption.
Not a fit: Patients who do not consume alcohol or have liver disease unrelated to alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve liver health and outcomes for individuals suffering from alcohol-associated liver disease.
How similar studies have performed: Other research has shown promising results in targeting phosphodiesterases for various conditions, suggesting that this approach may yield beneficial outcomes for alcohol-associated liver disease as well.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Gobejishvili, Leila — University of Louisville
- Study coordinator: Gobejishvili, Leila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.