Investigating how a specific enzyme affects liver disease caused by alcohol
Phosphodiesterase 4 mediated pathogenic mechanisms in alcohol associated liver disease
This study is looking at how a specific enzyme called PDE4 affects liver damage caused by alcohol, with the hope of finding new ways to help people with alcohol-related liver disease feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Louisville NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project ID | NIH-11098865 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of phosphodiesterase 4 (PDE4) in alcohol-associated liver disease (ALD), which affects a significant portion of the population. The study examines how alcohol influences the expression of PDE4 in the liver and its impact on liver cell function and injury. By using animal and cell models, researchers aim to uncover the mechanisms by which PDE4 contributes to liver damage and how inhibiting this enzyme may protect against liver injury. The ultimate goal is to identify new therapeutic targets for treating ALD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with alcohol-associated liver disease or those at risk due to heavy alcohol consumption.
Not a fit: Patients with liver disease not related to alcohol consumption may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve liver health and outcomes for patients suffering from alcohol-associated liver disease.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in liver disease, indicating potential for success in this approach.
Where this research is happening
Louisville, United States
- University of Louisville — Louisville, United States (Active)
Researchers
- Principal investigator: Gobejishvili, Leila — University of Louisville
- Study coordinator: Gobejishvili, Leila
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.