Investigating how a specific enzyme affects inflammation in the heart after a heart attack
The role of ATP citrate lyase in cardiac macrophage-mediated inflammation aftermyocardial infarction
This study is looking at how a specific enzyme in the heart affects inflammation after a heart attack, which could help us understand why some people have more heart problems afterward, and it aims to find ways to help those patients feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10925500 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of ATP citrate lyase (ACLY) in the inflammation that occurs in the heart following a myocardial infarction (heart attack). The study aims to explore how this enzyme influences the behavior of macrophages, a type of immune cell, and whether it contributes to increased inflammation and heart damage. By examining the metabolic pathways and epigenetic changes in cardiac macrophages, the research seeks to uncover mechanisms that lead to complications like heart failure. Patients who have experienced a heart attack may benefit from insights gained through this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently suffered a myocardial infarction, particularly those with ongoing inflammation or complications.
Not a fit: Patients who have not experienced a myocardial infarction or those with unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve recovery outcomes for heart attack patients.
How similar studies have performed: Previous studies have shown that targeting inflammation can significantly improve outcomes in heart attack patients, suggesting that this approach may yield valuable insights.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Dutta, Partha — Veterans Health Administration
- Study coordinator: Dutta, Partha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.