Investigating how a specific enzyme affects HIV replication
Ectodomain shedding and HIV replication
This study is looking at how a specific enzyme called ADAM10 affects the way HIV-1 spreads and replicates, with the hope that understanding this process can help develop new treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11026393 on NIH RePORTER |
What this research studies
This research focuses on the role of the enzyme ADAM10 in the lifecycle of HIV-1, particularly how it interacts with the virus's proteins to influence its replication and infectivity. By examining how ADAM10 cleaves the HIV-1 protein gp41, the study aims to understand the mechanisms that allow the virus to spread and how this process can be inhibited. The research will involve laboratory experiments using human CD4+ T cells to observe the effects of ADAM10 on HIV-1 transmission and replication. Patients may benefit from insights gained that could lead to new therapeutic strategies against HIV.
Who could benefit from this research
Good fit: Ideal candidates for participation would include individuals living with HIV, particularly those with Nef-deficient strains of the virus.
Not a fit: Patients who are not infected with HIV or those with advanced AIDS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit HIV replication, improving outcomes for patients living with HIV/AIDS.
How similar studies have performed: Previous research has shown that targeting viral replication mechanisms can lead to significant advancements in HIV treatment, suggesting potential success for this approach.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Gottlinger, Heinrich — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Gottlinger, Heinrich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.