Investigating how a specific enzyme affects HIV replication
Official title: Ectodomain shedding and HIV replication
Funded at Univ of Massachusetts Med Sch Worcester · NIH-11026393 · Data updated 2026-11-12
This study is looking at how a specific enzyme called ADAM10 affects the way HIV-1 spreads and replicates, with the hope that understanding this process can help develop new treatments for people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | February 5, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $714,334 |
| NIH project number | 5R01AI184042-02 |
| Project ID | NIH-11026393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation would include individuals living with HIV, particularly those with Nef-deficient strains of the virus.
✕Less likely to help
Patients who are not infected with HIV or those with advanced AIDS may not benefit from this research.
What this research studies
This research focuses on the role of the enzyme ADAM10 in the lifecycle of HIV-1, particularly how it interacts with the virus's proteins to influence its replication and infectivity. By examining how ADAM10 cleaves the HIV-1 protein gp41, the study aims to understand the mechanisms that allow the virus to spread and how this process can be inhibited. The research will involve laboratory experiments using human CD4+ T cells to observe the effects of ADAM10 on HIV-1 transmission and replication. Patients may benefit from insights gained that could lead to new therapeutic strategies against HIV.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that inhibit HIV replication, improving outcomes for patients living with HIV/AIDS.
How similar studies have gone: Previous research has shown that targeting viral replication mechanisms can lead to significant advancements in HIV treatment, suggesting potential success for this approach.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Gottlinger, Heinrich — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Gottlinger, Heinrich
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.