Investigating how a specific enzyme affects heart tissue scarring and heart failure.
Official title: 15-PGDH-Mediated Eicosanoid Degradation in Cardiac Fibrosis and Heart Failure
Funded at University of Colorado Denver · NIH-11134751 · Data updated 2026-11-12
This study is looking at how a specific enzyme affects heart scarring and stiffness, and it aims to find ways to stop this process to help people with heart failure feel better and improve their heart function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | July 10, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $544,291 |
| NIH project number | 5R01HL171711-02 |
| Project ID | NIH-11134751 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing heart failure or related cardiac conditions.
✕Less likely to help
Patients with acute heart failure or those without any signs of cardiac fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding the role of an enzyme called 15-PGDH in the development of cardiac fibrosis, which is the thickening and scarring of heart tissue. The study aims to explore how inhibiting this enzyme can prevent the activation of cardiac fibroblasts, the cells responsible for fibrosis, thereby potentially reducing heart stiffness and improving heart function. By using both animal models and human samples, the research seeks to identify new therapeutic strategies for treating heart failure with preserved ejection fraction (HFpEF). Patients may be monitored for changes in heart structure and function through advanced imaging techniques.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse heart failure caused by cardiac fibrosis.
How similar studies have gone: Previous research has shown promising results in using similar approaches to target cardiac fibrosis, indicating potential for success in this area.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Mckinsey, Timothy — University of Colorado Denver
- Study coordinator: Mckinsey, Timothy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.