Investigating how a specific enzyme affects chronic pain signaling
A role for peripheral NAAA-regulated lipid signaling in the control of hyperalgesic priming
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10784207
This study is looking at how a specific enzyme called NAAA might play a role in turning short-term pain into long-lasting pain, with the hope of finding new ways to help people manage chronic pain better.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10784207 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the molecular mechanisms behind chronic pain, which affects millions of adults in the U.S. The study specifically examines the role of the enzyme N-Acylethanolamine Acid Amidase (NAAA) in the transition from acute to chronic pain. By exploring how NAAA influences pain signaling pathways, the research aims to identify potential new targets for pain management. Patients may benefit from insights that could lead to safer and more effective treatments for chronic pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic pain conditions.
Not a fit: Patients with acute pain that has not transitioned to a chronic state may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic pain more effectively.
How similar studies have performed: Previous research has shown promising results in understanding pain mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOTIO, YANNICK — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: FOTIO, YANNICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.