Investigating how a specific enzyme affects chronic pain signaling
Official title: A role for peripheral NAAA-regulated lipid signaling in the control of hyperalgesic priming
Funded at University of California-Irvine · NIH-10784207 · Data updated 2026-11-12
This study is looking at how a specific enzyme called NAAA might play a role in turning short-term pain into long-lasting pain, with the hope of finding new ways to help people manage chronic pain better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $238,276 |
| NIH project number | 1K99AT012658-01 |
| Project ID | NIH-10784207 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic pain conditions.
✕Less likely to help
Patients with acute pain that has not transitioned to a chronic state may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind chronic pain, which affects millions of adults in the U.S. The study specifically examines the role of the enzyme N-Acylethanolamine Acid Amidase (NAAA) in the transition from acute to chronic pain. By exploring how NAAA influences pain signaling pathways, the research aims to identify potential new targets for pain management. Patients may benefit from insights that could lead to safer and more effective treatments for chronic pain.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic pain more effectively.
How similar studies have gone: Previous research has shown promising results in understanding pain mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Fotio, Yannick — University of California-Irvine
- Study coordinator: Fotio, Yannick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.