Investigating how a specific enzyme affects brain cell function and diseases.
Chemical Biology of the E3 Ubiqutin Ligase Nedd4
This study is looking at how a specific enzyme called Nedd4 affects the harmful protein alpha-synuclein, which is linked to diseases like Parkinson's, to find new ways to help manage or treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11009593 on NIH RePORTER |
What this research studies
This research focuses on the role of the Nedd4 enzyme in regulating cellular processes related to neurodegenerative diseases, particularly those involving the protein alpha-synuclein. By exploring how Nedd4 influences the toxicity associated with alpha-synuclein, the research aims to identify new therapeutic targets for conditions like Parkinson's disease. The approach includes using small molecules that can modify Nedd4's activity and studying their effects on cellular models. Patients may benefit from insights gained into how to better manage or treat neurodegenerative disorders linked to protein aggregation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with neurodegenerative disorders, particularly those related to alpha-synuclein, such as Parkinson's disease.
Not a fit: Patients with neurodegenerative diseases not associated with alpha-synuclein or those without any neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurodegenerative diseases characterized by protein aggregation.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in neurodegenerative diseases, suggesting potential for success in this approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Mccafferty, Dewey G — Duke University
- Study coordinator: Mccafferty, Dewey G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.