Investigating how a specific enzyme affects bone development
Official title: The Role of Ubiquitin Conjugating Enzyme (Ubc9) in Endochondral Ossification
Funded at University of Alabama at Birmingham · NIH-11056678 · Data updated 2026-11-12
This study is looking at how a special enzyme called Ubc9 helps with the growth of bones during the early development of mice, to better understand how problems in this process might lead to bone disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | March 13, 2024 |
| Project end | March 12, 2027 |
| Funding year | 2025 |
| Award (this year) | $57,774 |
| NIH project number | 5F30DE033624-02 |
| Project ID | NIH-11056678 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants and young children with skeletal development issues or related disorders.
✕Less likely to help
Patients with fully developed skeletal systems or those not experiencing any bone-related conditions may not benefit from this research.
What this research studies
This research focuses on understanding the role of Ubc9, an enzyme involved in a process called SUMOylation, which modifies proteins and is crucial for cell growth and tissue development. The study examines how SUMOylation influences the formation of skeletal tissue during embryonic development, particularly in mice. By analyzing the expression levels of key genes involved in bone formation, the research aims to uncover the mechanisms that regulate bone development and how abnormalities in these processes may lead to skeletal disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights into bone development and potential treatments for skeletal disorders.
How similar studies have gone: Previous research has shown that understanding post-translational modifications like SUMOylation can lead to significant advancements in treating related disorders, indicating a promising avenue for this investigation.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Mccullough, Kayla R — University of Alabama at Birmingham
- Study coordinator: Mccullough, Kayla R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.