Investigating how a specific enzyme affects blood vessel function and organ injury during heart surgery
The effects of soluble guanylyl cyclase stimulation on perioperative vascular reactivity and organ injury in cardiac surgery trial
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10917127
This study is looking at how a specific enzyme affects blood vessel function and can lead to problems like kidney and brain injuries during heart surgery, with the goal of finding ways to help patients recover better and stay healthier after their procedures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10917127 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of soluble guanylyl cyclase in regulating blood vessel function and its impact on organ injuries, particularly acute kidney and brain injuries, during cardiac surgery. The study aims to explore how disruptions in vascular reactivity can lead to complications such as delirium and longer hospital stays for patients. By examining the mechanisms behind these injuries, the research seeks to identify potential therapeutic targets that could improve patient outcomes. Patients undergoing cardiac surgery may be monitored for changes in vascular function and organ health throughout the surgical process.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for cardiac surgery who may be at risk for acute kidney or brain injuries.
Not a fit: Patients who are not undergoing cardiac surgery or those with pre-existing severe organ dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ injuries during cardiac surgery, ultimately enhancing recovery and reducing complications for patients.
How similar studies have performed: Previous research has indicated that targeting vascular reactivity can lead to improved outcomes in similar patient populations, suggesting a promising avenue for this investigation.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOPEZ, MARCOS G — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: LOPEZ, MARCOS G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury