Investigating how a specific drug affects fat metabolism in humans
Effect of PDE5 Inhibition on Adipose Metabolism in Humans
This study is looking at how blocking a specific enzyme might help change fat in your body to burn more energy, which could lead to new ways to treat obesity and related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11012787 on NIH RePORTER |
What this research studies
This research explores the effects of inhibiting an enzyme called phosphodiesterase type 5A (PDE5) on fat metabolism in humans, particularly focusing on transforming white adipose tissue into a more metabolically active form known as brown adipose tissue. The study utilizes advanced magnetic resonance imaging techniques to non-invasively measure changes in fat tissue and metabolism. By understanding how PDE5 inhibition can stimulate fat metabolism, the research aims to identify potential new treatments for obesity and related metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who are overweight or obese and interested in potential treatments for weight management.
Not a fit: Patients who are not overweight or obese may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for weight loss and improved metabolic health in individuals with obesity.
How similar studies have performed: Previous research has shown promising results in animal models regarding the effects of PDE5 inhibition on fat metabolism, but this approach is relatively novel in human studies.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Brittain, Evan L — Vanderbilt University Medical Center
- Study coordinator: Brittain, Evan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.