Investigating how a specific chloride transporter affects brain function in models of psychiatric disorders
NKCC1-KCC2 system modulation in rodent models relevant for psychiatric disorders
This study is looking at how a specific brain system affects thinking and social behavior in models of schizophrenia, and it tests whether a medication called bumetanide can help improve brain function and cognitive skills in people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11114186 on NIH RePORTER |
What this research studies
This research explores the role of the NKCC1-KCC2 system in the brain, particularly how it influences cognitive function and social behavior in models of schizophrenia. By using rodent models treated with phencyclidine, which simulates cognitive impairment, the study examines how the balance of excitation and inhibition in the brain is disrupted. The researchers aim to determine if a drug called bumetanide can restore normal brain function and improve cognitive performance. This approach could lead to new treatment strategies for individuals with psychiatric disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with schizophrenia or related neurodevelopmental disorders.
Not a fit: Patients with psychiatric disorders not related to cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for improving cognitive function in patients with schizophrenia and related disorders.
How similar studies have performed: Previous research has shown promising results using similar approaches to restore cognitive function in animal models of psychiatric disorders.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Martina, Marco — Northwestern University at Chicago
- Study coordinator: Martina, Marco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.