Investigating how a specific chloride transporter affects brain function in models of psychiatric disorders

Who could benefit from this research

What this research studies

This research explores the role of the NKCC1-KCC2 system in the brain, particularly how it influences cognitive function and social behavior in models of schizophrenia. By using rodent models treated with phencyclidine, which simulates cognitive impairment, the study examines how the balance of excitation and inhibition in the brain is disrupted. The researchers aim to determine if a drug called bumetanide can restore normal brain function and improve cognitive performance. This approach could lead to new treatment strategies for individuals with psychiatric disorders.

Why it matters

Where this research is happening

• Northwestern University at Chicago
  Chicago, United States Active

Researchers

• Principal investigator: Martina, Marco — Northwestern University at Chicago
• Study coordinator: Martina, Marco

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.