Investigating how a specific chloride channel in the brain works using small molecules
Small-molecule probes for study of CLC-2 chloride-channel function in the central nervous system
This study is looking at how a specific brain channel called CLC-2 works and how a new medicine, FA44, can help us learn more about it, which could lead to better treatments for brain-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10782523 on NIH RePORTER |
What this research studies
This research focuses on understanding the function of the CLC-2 chloride channel, which plays a crucial role in neuronal signaling and brain function. Researchers have developed a selective small-molecule inhibitor, FA44, that targets CLC-2, allowing for detailed studies of its physiological role in the brain. By using advanced techniques, including compound-library screening and electrophysiological recordings, the project aims to uncover how CLC-2 contributes to brain activity and overall health. This could lead to new insights into neurological conditions and potential therapeutic approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that may be influenced by chloride channel activity.
Not a fit: Patients with conditions unrelated to chloride channel function or those not experiencing neurological issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for neurological disorders linked to chloride channel dysfunction.
How similar studies have performed: Previous research has shown promise in targeting chloride channels for therapeutic purposes, indicating potential success for this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Maduke, Merritt C — Stanford University
- Study coordinator: Maduke, Merritt C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.