Investigating how a specific cellular process affects aging and cell health
Official title: Role of Chaperone-Mediated Autophagy in Cellular Senescence
Funded at Albert Einstein College of Medicine · NIH-10899927 · Data updated 2026-11-12
This study is looking at how a process called chaperone-mediated autophagy (CMA) affects aging and the buildup of old cells in our bodies, with the hope of finding ways to improve health and longevity as we get older.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31AG084192-01A1 |
| Project ID | NIH-10899927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or those with conditions linked to cellular senescence.
✕Less likely to help
Patients who are young and do not have any age-related conditions may not receive direct benefits from this research.
What this research studies
This research explores the relationship between chaperone-mediated autophagy (CMA) and cellular senescence, which are both important factors in the aging process. It aims to understand how changes in CMA activity may influence the accumulation of senescent cells, which can lead to various age-related diseases. By examining the role of CMA in the clearance of these cells, the research seeks to uncover potential mechanisms that contribute to aging and cellular dysfunction. Patients may benefit from insights gained about how to enhance cellular health and longevity.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cellular health and potentially delaying the onset of age-related diseases.
How similar studies have gone: While the specific interplay between CMA and senescence is less explored, related research has shown promise in understanding cellular aging and its implications for health.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Sereda, Rebecca Z — Albert Einstein College of Medicine
- Study coordinator: Sereda, Rebecca Z
Related research
Other NIH-funded projects on the same topics.
-
Participatory system dynamics to improve PrEP access in the Bronx
A community-driven project in the Bronx will use system dynamics to identify practical ways to help people at risk for HIV start and stay on PrEP.
-
Collaborative research network program for advancements in health science
A NIH-funded multi-institution project aims to advance health science through coordinated research efforts over five years for potential patient benefits.
-
Collaborative NIH Initiative to Advance Health
A national team project aims to make progress in a broad health area with potential benefits for patients.
-
A decentralized, post-incarceration program to help people living with or at risk for HIV
A patient-facing program called DEST2nation aims to help people recently released from jail or prison stay on HIV treatment (ART) and prevention (PrEP) by coordinating care, housing, and support services through peers and community organizations.
-
Project-002: a patient-facing look at a multi-institution effort
A concise, patient-friendly overview of a multi-site NIH project that may explore new approaches to health care over several years.
-
Plug-and-play vaccine and antibody blueprints for emerging flu-like viruses
A multi-team NIH grant aims to create adaptable vaccine and antibody blueprints to rapidly respond to new enveloped RNA viruses in three families.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.