Investigating how a specific cell death process in neurons affects inflammation and cognitive function in aging.
Official title: Effect of Necroptosis in Neurons on Neuroinflammation, Neuronal Function, and Cognition.
Funded at Oklahoma City VA Medical Center · NIH-11062150 · Data updated 2026-11-12
This study is looking at how a specific type of cell death in the brain, called necroptosis, affects brain health and thinking as we age, with the hope of finding new ways to help people deal with memory and thinking problems that come with getting older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma City VA Medical Center NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| NIH project number | 1I01BX007006-01 |
| Project ID | NIH-11062150 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing age-related cognitive decline or neuroinflammation.
✕Less likely to help
Patients with acute neurological injuries or those under 21 years old may not benefit from this research.
What this research studies
This research explores the role of necroptosis, a type of cell death, in the aging brain and its connection to chronic inflammation, known as inflammaging. The study aims to understand how necroptosis in neurons influences neuronal function and cognition without causing cell death. By examining the mechanisms involved, the research seeks to identify potential therapeutic targets to mitigate the effects of aging on brain health. Patients may benefit from insights that could lead to new treatments for age-related cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline associated with aging and neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in aging, but the specific focus on necroptosis in neurons is a novel approach.
Where this research is happening
-
Oklahoma City VA Medical Center
Oklahoma City, United States Active
Researchers
- Principal investigator: Richardson, Arlan G. — Oklahoma City VA Medical Center
- Study coordinator: Richardson, Arlan G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.