Investigating how a specific calcium channel affects lung injury after transplantation
Role of TRPV4 channel signaling in lung ischemia-reperfusion injury
This study is looking at how a specific channel in lung cells, called TRPV4, might cause inflammation and damage after a lung transplant, with the hope of finding ways to protect the lungs and improve transplant success for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-10819199 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the TRPV4 calcium channel in lung ischemia-reperfusion injury, a condition that can occur after lung transplantation. The study aims to explore how TRPV4 activation leads to inflammation and damage in lung tissues, which can affect the success of transplants. By examining the mechanisms of TRPV4 signaling in various lung cells, the research seeks to identify potential therapeutic targets that could protect against this injury. Patients may benefit from insights gained that could improve lung transplant outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing or considering lung transplantation.
Not a fit: Patients with lung conditions unrelated to transplantation or those not eligible for lung transplant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce lung injury and improve the success rates of lung transplants.
How similar studies have performed: Previous research has shown that targeting calcium channels can be beneficial in other forms of organ injury, suggesting potential for success in this area.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Laubach, Victor E — University of Virginia
- Study coordinator: Laubach, Victor E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.