Investigating how a specific bacterial secretion system affects infections and cancer development.
Official title: Type VII secretion in Streptococcus gallolyticus pathogenesis
Funded at Texas A&m University Health Science Ctr · NIH-10991386 · Data updated 2026-11-12
This study is looking at how a germ called Streptococcus gallolyticus affects the gut and can lead to serious infections and colorectal cancer, with the goal of finding new ways to prevent these health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | December 1, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $366,305 |
| NIH project number | 5R01AI163206-02 |
| Project ID | NIH-10991386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of colorectal cancer or those experiencing severe bacterial infections.
✕Less likely to help
Patients without any history of colorectal cancer or related bacterial infections may not benefit from this research.
What this research studies
This research focuses on the bacterium Streptococcus gallolyticus, which is linked to serious bloodstream infections and colorectal cancer. The study aims to understand how this bacterium interacts with the intestinal lining and contributes to disease progression. By examining the role of a specific secretion system in the bacterium, researchers hope to uncover mechanisms that lead to increased cancer cell growth and infection severity. The findings could provide insights into potential therapeutic targets for preventing these serious health issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating infections and colorectal cancer associated with Streptococcus gallolyticus.
How similar studies have gone: Previous research has shown promising results in understanding bacterial interactions with host tissues, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Xu, Yi — Texas A&m University Health Science Ctr
- Study coordinator: Xu, Yi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.