Investigating how a specific bacteria affects oral health around dental implants
Official title: Commensal modulation of Peri-implant Microbiome Dysbiosis via Veillonella parvula
Funded at Rutgers Biomedical and Health Sciences · NIH-11137405 · Data updated 2026-11-12
This study is looking at how tiny titanium particles from dental implants affect the bacteria in your mouth, especially a type called Veillonella parvula, to help find better ways to manage peri-implantitis, a condition that can harm your dental implants and overall oral health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $233,693 |
| NIH project number | 3R01DE031746-03S1 |
| Project ID | NIH-11137405 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with dental implants who are experiencing or at risk for peri-implantitis.
✕Less likely to help
Patients without dental implants or those not experiencing peri-implantitis may not benefit from this research.
What this research studies
This research focuses on peri-implantitis, a serious inflammatory condition that causes bone loss around dental implants and negatively impacts oral health. The study aims to understand how titanium particles from implants influence the microbiome in the mouth, particularly the role of the bacteria Veillonella parvula in surviving oxidative stress. By examining the genetic mechanisms of this bacteria, the research seeks to uncover how it interacts with other pathogens in the presence of titanium-induced inflammation. This could lead to new insights into managing peri-implantitis more effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from peri-implantitis, enhancing their oral health and quality of life.
How similar studies have gone: Previous research has shown that understanding the microbiome's role in oral health can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Kotsakis, Georgios — Rutgers Biomedical and Health Sciences
- Study coordinator: Kotsakis, Georgios
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.