Investigating how a specific bacteria affects oral health around dental implants
Commensal modulation of Peri-implant Microbiome Dysbiosis via Veillonella parvula
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-11137405
This study is looking at how tiny titanium particles from dental implants affect the bacteria in your mouth, especially a type called Veillonella parvula, to help find better ways to manage peri-implantitis, a condition that can harm your dental implants and overall oral health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-11137405 on ClinicalTrials.gov |
What this research studies
This research focuses on peri-implantitis, a serious inflammatory condition that causes bone loss around dental implants and negatively impacts oral health. The study aims to understand how titanium particles from implants influence the microbiome in the mouth, particularly the role of the bacteria Veillonella parvula in surviving oxidative stress. By examining the genetic mechanisms of this bacteria, the research seeks to uncover how it interacts with other pathogens in the presence of titanium-induced inflammation. This could lead to new insights into managing peri-implantitis more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with dental implants who are experiencing or at risk for peri-implantitis.
Not a fit: Patients without dental implants or those not experiencing peri-implantitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from peri-implantitis, enhancing their oral health and quality of life.
How similar studies have performed: Previous research has shown that understanding the microbiome's role in oral health can lead to significant advancements in treatment strategies, suggesting this approach has potential for success.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOTSAKIS, GEORGIOS — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: KOTSAKIS, GEORGIOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.