Investigating how a specific bacteria adapts to infect human cells
Evaluating Mycobacterium avium glycopeptidolipids as key factors in the transition from biofilm to macrophages
This study is looking at how a type of bacteria called Mycobacterium avium changes from living in clusters to invading our immune cells, and it hopes to find ways to improve diagnosis and treatment for infections, especially for older adults who may be more at risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project ID | NIH-10582714 on NIH RePORTER |
What this research studies
This research focuses on understanding how the bacteria Mycobacterium avium transitions from living in biofilms to invading human immune cells called macrophages. It examines the role of glycopeptidolipids, which are important molecules on the bacteria's surface, in this process. By studying this transition, the research aims to uncover mechanisms that could lead to better diagnosis and treatment options for infections caused by this bacteria, particularly in vulnerable populations such as the elderly. The approach involves laboratory experiments to analyze bacterial behavior and interactions with immune cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals or those with weakened immune systems who are at risk for or currently suffering from Mycobacterium avium infections.
Not a fit: Patients who are not elderly or do not have compromised immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for pulmonary infections caused by Mycobacterium avium, particularly benefiting older adults who are at higher risk.
How similar studies have performed: While the specific focus on glycopeptidolipids in Mycobacterium avium is novel, similar studies on bacterial adaptations have shown promise in understanding infectious diseases.
Where this research is happening
Notre Dame, United States
- University of Notre Dame — Notre Dame, United States (Active)
Researchers
- Principal investigator: Schorey, Jeffrey Scott — University of Notre Dame
- Study coordinator: Schorey, Jeffrey Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.