Investigating how a serotonin receptor affects breathing responses in newborns and its link to Sudden Infant Death Syndrome.
Official title: The role of the Htr1B serotonin receptor in the neonate autoresuscitation reflex and embryonic serotonergic neurogenesis as a potential mechanism in Sudden Infant Death Syndrome
Funded at Baylor College of Medicine · NIH-10901065 · Data updated 2026-11-12
This study is looking at how a specific brain receptor related to serotonin might affect how newborns can restart their breathing after they stop for a moment, which is important for understanding Sudden Infant Death Syndrome (SIDS) and finding ways to help prevent it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL168962-01A1 |
| Project ID | NIH-10901065 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include infants under one year of age, particularly those who may be at risk for SIDS.
✕Less likely to help
Patients who are older than one year or those without any risk factors for SIDS may not benefit from this research.
What this research studies
This research focuses on understanding the role of the Htr1B serotonin receptor in newborns, particularly how it may influence the autoresuscitation reflex, which is the body's ability to restart breathing after an episode of apnea. The study will involve examining brainstem abnormalities and serotonin levels in infants who have experienced Sudden Infant Death Syndrome (SIDS). By analyzing these factors, researchers aim to uncover the mechanisms that could lead to better prevention strategies for SIDS. The approach includes post-mortem studies and neurogenesis assessments to explore the relationship between serotonin signaling and respiratory control in neonates.
Why it matters
Potential benefit: If successful, this research could lead to new insights and interventions that may reduce the risk of Sudden Infant Death Syndrome in infants.
How similar studies have gone: Previous studies have indicated potential links between serotonin levels and SIDS, suggesting that this research could build on existing knowledge in a promising area.
Where this research is happening
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Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Patel, Dipak — Baylor College of Medicine
- Study coordinator: Patel, Dipak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.