Investigating how a red blood cell enzyme affects cognitive impairment after stroke
Red Blood Cell BPGM Deficiency Contributes to Cognitive Impairment Following Ischemic Stroke
['FUNDING_R21'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11035374
This study is looking at how a certain enzyme in your red blood cells might affect thinking and memory problems after a stroke, with the hope of finding new ways to help stroke survivors who are struggling with these issues.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11035374 on ClinicalTrials.gov |
What this research studies
This research explores the role of a specific enzyme in red blood cells, bisphosphoglycerate mutase (BPGM), in contributing to cognitive impairment in stroke survivors. The study aims to understand how lower levels of BPGM may lead to reduced oxygen delivery to the brain and potentially worsen cognitive decline. By examining the relationship between red blood cells, brain blood vessels, and cognitive function, the researchers hope to identify new pathways for early diagnosis and intervention. The findings could lead to better management strategies for stroke patients experiencing cognitive issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are stroke survivors who are experiencing cognitive impairment.
Not a fit: Patients who have not experienced a stroke or do not have cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for cognitive impairment in stroke survivors.
How similar studies have performed: Previous research has indicated that understanding the role of red blood cells in cognitive impairment could lead to significant advancements, suggesting this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENG, WENJUN — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: DENG, WENJUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.