Investigating how a protein related to spinal muscular atrophy interacts with specific molecules in cells
DMA-Tudor interaction modules: a novel approach to Survival Motor Neuron protein (SMN) and Cajal body function
This study is looking at a protein called SMN that is important for keeping motor neurons healthy, and it's trying to find out how it interacts with certain molecules to better understand what happens in Spinal Muscular Atrophy (SMA), which could help in finding new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10871709 on NIH RePORTER |
What this research studies
This research focuses on the Survival Motor Neuron protein (SMN), which is crucial for motor neuron health and is linked to Spinal Muscular Atrophy (SMA). The study aims to understand how SMN interacts with molecules modified by dimethylarginine (DMA) and how these interactions affect cellular organization, particularly in the neuromuscular system. By identifying the DMA ligands that bind to SMN, the research seeks to uncover the molecular mechanisms behind motoneuron loss in SMA. This could lead to new insights into the disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Spinal Muscular Atrophy or those at risk due to genetic factors.
Not a fit: Patients with other neurological disorders unrelated to SMN deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Spinal Muscular Atrophy, potentially improving outcomes for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of biomolecular condensates in neurological diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Neugebauer, Karla M — Yale University
- Study coordinator: Neugebauer, Karla M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.