Investigating how a protein related to Alzheimer's may protect the lungs from injury
Official title: The amyloid precursor protein protects against acute lung injury
Funded at University of South Alabama · NIH-10905988 · Data updated 2026-11-12
This study is looking at how a protein called APP helps protect the lungs during infections, especially from a bacteria that can cause serious problems, and it’s for anyone interested in understanding how our immune system works and how we might improve treatments for lung injuries.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Alabama NIH-funded |
| Lab location | 1 site (Mobile, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $192,500 |
| NIH project number | 5R21AI174215-02 |
| Project ID | NIH-10905988 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of acute lung injury or those at risk of lung infections.
✕Less likely to help
Patients with chronic lung diseases unrelated to acute infections may not benefit from this research.
What this research studies
This research explores the role of the amyloid precursor protein (APP) in protecting the lungs during infections, particularly from the bacteria Pseudomonas aeruginosa. It examines how APP influences neutrophil behavior, which is crucial for fighting infections but can also cause tissue damage. By studying mice with and without APP, the research aims to understand how this protein affects lung injury and immune response. The findings could lead to new insights into treating acute lung injuries and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung protection during infections, potentially improving outcomes for patients with acute lung injuries.
How similar studies have gone: Other research has shown that targeting immune responses can be beneficial in treating infections, suggesting potential success for this approach.
Where this research is happening
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University of South Alabama
Mobile, United States Active
Researchers
- Principal investigator: Audia, Jonathon Peter — University of South Alabama
- Study coordinator: Audia, Jonathon Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.