Investigating how a protein regulates the cell cycle and its implications for diseases.
Structure and Function of the Essential Cell Cycle Regulator Cdc34
This study is looking at how a tiny protein called ubiquitin helps control important processes in our cells, like how they grow and repair themselves, which could lead to new treatments for diseases like cancer and heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11041102 on NIH RePORTER |
What this research studies
This research focuses on the role of ubiquitin, a small protein that modifies other proteins, in regulating essential cellular processes such as the cell cycle, DNA repair, and immune responses. By studying how ubiquitination affects protein stability and activity, the research aims to uncover mechanisms that could lead to new treatments for diseases like cancer and cardiovascular disorders. The project utilizes advanced biochemical assays and molecular biology techniques to explore the interactions between ubiquitin and its target proteins, particularly in the context of cell cycle regulation. Patients may benefit from insights gained into how disruptions in these processes contribute to disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers or cardiovascular diseases that may be influenced by cell cycle regulation.
Not a fit: Patients with conditions unrelated to cell cycle regulation or those not affected by ubiquitin signaling may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating cancers and other diseases linked to cell cycle dysregulation.
How similar studies have performed: Previous research has shown that targeting ubiquitin signaling can be effective in treating certain cancers, indicating a promising avenue for further exploration.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Olsen, Shaun — University of Texas Hlth Science Center
- Study coordinator: Olsen, Shaun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.