Investigating how a protein protects chromosomes in mammalian cells
Cell Biology of Mammalian Nuclei
This study is looking at how a protein called Ki-67 helps keep our DNA safe during cell division, which is important for understanding how tumors grow and finding new ways to treat cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11140287 on NIH RePORTER |
What this research studies
This research focuses on the role of the Ki-67 protein in maintaining chromosome integrity during cell division. It examines how Ki-67 organizes chromatin and protects DNA from damage, particularly during mitosis. The study involves analyzing the protein's interactions with chromosomes and identifying specific regions in the genome where its protective effects are most critical. By understanding these mechanisms, the research aims to uncover insights into tumor growth and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers where Ki-67 is a relevant tumor marker or those at risk of developing such cancers.
Not a fit: Patients with non-cancerous conditions or those not affected by chromosome instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing DNA damage in cancer cells, potentially improving cancer treatment outcomes.
How similar studies have performed: Previous research has shown promising results in understanding the role of proteins like Ki-67 in cancer biology, indicating that this approach has potential for significant findings.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Kaufman, Paul D. — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Kaufman, Paul D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.