Investigating how a protein on blood vessel cells affects blood clotting
Official title: Chemoenzymatic Semisynthesis of Proteoglycan and Its Cofactor Activities
Funded at Cleveland State University · NIH-11041503 · Data updated 2026-11-12
This study is looking at a protein called thrombomodulin that helps control blood clotting, to see how it works with other proteins and fats in our cells, which could lead to better understanding and treatments for blood clotting disorders.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland State University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | January 15, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $445,500 |
| NIH project number | 1R15HL177621-01 |
| Project ID | NIH-11041503 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to blood coagulation, such as hemophilia or thrombosis.
✕Less likely to help
Patients with unrelated conditions or those not experiencing blood coagulation issues may not benefit from this research.
What this research studies
This research focuses on thrombomodulin (TM), a protein found on the surface of blood vessel cells that plays a crucial role in regulating blood clotting. The study aims to understand how TM interacts with other proteins involved in coagulation, specifically protein C and TAFI, and how these interactions are influenced by the surrounding cell membrane lipids. By examining these mechanisms, the research seeks to clarify whether these proteins compete for binding to TM and how this affects blood coagulation processes. Patients may benefit from insights gained about blood clotting disorders and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for blood clotting disorders, enhancing patient outcomes.
How similar studies have gone: Previous studies have shown promising results in understanding the role of thrombomodulin in coagulation, indicating that this research builds on established findings.
Where this research is happening
-
Cleveland State University
Cleveland, United States Active
Researchers
- Principal investigator: Sun, Xue-Long — Cleveland State University
- Study coordinator: Sun, Xue-Long
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.