Investigating how a protein modification affects neurodegenerative diseases like ALS and Alzheimer's.
Defining the Role of Poly ADP-ribose in Biomolecular Condensation in ALS and FTLD
This study is looking at how a protein called PAR might play a role in diseases like ALS and Alzheimer's, and the researchers at Boston Children's Hospital hope to find new ways to help people with these conditions by understanding how PAR affects the buildup of harmful proteins in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10758000 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of poly ADP-ribose (PAR), a protein modification linked to neurodegenerative diseases such as ALS and Alzheimer's. The team at Boston Children's Hospital will use advanced imaging and biochemical techniques to explore how PAR contributes to the formation of stress granules and protein aggregation, which are associated with these conditions. By studying the mechanisms of PAR-driven biomolecular condensation, the researchers aim to uncover new therapeutic strategies that could mitigate neurotoxicity in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with ALS, Alzheimer's disease, or related neurodegenerative conditions.
Not a fit: Patients with neurodegenerative diseases not related to ALS or Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of neurodegenerative diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of PAR in neurodegeneration, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Myong, Sua — Boston Children's Hospital
- Study coordinator: Myong, Sua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.